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Research Areas: Cores to Translate Therapies

Illustration of neurons in the brain

Research Areas

Age Related Memory Loss

Advances in medical research, and the growing new field of “Geroscience,” have enabled us to understand the aging process better, and to live longer; however, despite progress made on the understanding of cellular changes and loss that accompany aging, little progress has been made in treating cognitive problems, most notably the progressive decline in memory function. Learn More >

Brain Cancer

Brain tumors, unfortunately, seem to be becoming more prevalent, and a particular type of tumor, the glioma, is difficult to treat because of the propensity to recur even following surgical removal of the tumor mass. It is the difficulty of locating and inhibiting the growth of cancer cells that have migrated away from the tumor mass that makes gliomas so recalcitrant using existing radiation and chemotherapeutic approaches. Learn More >

CNS Injury

Injury to the central nervous system (CNS) including the brain and spinal cord are major health problems both nationally and internationally. More than 2 million people in the U.S. suffer traumatic brain injuries annually, well over 500,000 people per year suffer from stroke, and at least 10,000 people per year suffer spinal cord injuries. Most people suffering from CNS injuries must endure irreversible disabilities as a result of these insults. Learn More >

Chronic Neurological Diseases

Chronic neurological diseases — Parkinson’s disease, other movement disorders including dystonia, ALS and Huntington’s disease, Alzheimer’s disease, neuromuscular disease, multiple sclerosis, and epilepsy, to mention only a few — afflict millions of Americans worldwide and account for tremendous morbidity and mortality. Although treatments have been sought for these diseases, presently they are inadequate. Learn More >

Development, Regeneration, Rehabilitation

The field of restorative neuroscience has begun to appreciate that before we can develop new therapeutics for rebuilding a damaged brain, we must understand the cell and molecular interactions that occur during the original construction of our nervous system. During development of the brain and spinal cord, the expression of different genes and proteins contribute to an impressive plasticity in the formation of complex circuitries that bring about our magnificent repertoire of complex human behaviors. Learn More >

Mental Health, Neurobehavioral Sciences, and Psychiatry

The Neurobehavioral Sciences are becoming more and more appreciated for their potential to positively affect the quality of life for all people, since progress made in neuroscience has contributed new technologies to the armament of approaches for treating mental disorders. Examples of pioneering research being done in the clinical and basic science laboratories of the McKnight Brain Institute include the development of new brain stimulation protocols that improve behavioral outcomes for obsessive compulsive disorder, depression, and schizophrenia. Learn More >