UF neurologist presents new findings on Plavix/aspirin combo at AHA meeting

Dr. Alexis Simpkins head shotUniversity of Florida neurologist Alexis Simpkins, M.D., Ph.D., and colleagues at UF and top peer institutions presented their highly rated abstract “Secondary Stroke Prevention With Aspirin and Clopidogrel in CYP2C19*17 Carriers Increases Risk of Major Non-CNS Bleeding” at the American Heart Association’s Scientific Sessions meeting on Nov. 17.

The research team found that patients who have had a stroke in the past and are genetically more likely to convert the drug clopidogrel, or Plavix, into its active form are at high risk of having a major bleeding complication when they take both clopidogrel and aspirin long-term as a way to prevent another stroke.

“We still need more information about how well these findings translate to the general population outside of a clinical trial,” said Simpkins, clinical assistant professor in UF’s department of neurology. “The next step will be to look for similar findings in a separate patient population to validate our results.”

Read the abstract here.