Neurological Diseases

collage image of scientists working in their labs

The McKnight Brain Institute’s signature programs in neurological diseases include brain tumor immunotherapy and a range of neurodegenerative disorders including ALS, Alzheimer’s disease and Parkinson’s disease. The MBI is dedicated to accelerating discoveries in these fields to enhance brain health and develop innovative therapies.

1Florida Alzheimer’s Disease Research Center (1Florida ADRC)

Logo: 1 Florida A-D-R-C

The 1Florida ADRC is a UF-led consortium of five Florida institutions involving over 30 faculty members that evaluates people with and without memory disorders and other thinking problems for diagnosis and participation in research studies.

Learn more about the 1Florida ADRC.


Center for NeuroGenetics (CNG)

Doctors Laura Ranum and Lien Nguyen reviewing microscope images

The CNG integrates molecular, genetic, and clinical approaches to find the causes of neurodegenerative disease and develop effective treatment strategies.

Learn more about the CNG.


Center for Translational Research in Neurodegenerative Disease (CTRND)

Dr. Matt Hamm

The CTRND is an innovative, multidisciplinary research center focused on the discovery, development, and evaluation of future treatments and diagnostics for degenerative central nervous system conditions.

Learn more about the CTRND.


Preston A. Wells, Jr. Center for Brain Tumor Therapy

Doctor Elias talking to fellow researchers at a hooded ventilator machine

This center serves as a hub for some of the brightest minds in the fields of neuro-oncology, neurosurgery, and radiation oncology where leading researchers and their teams collaborate with physicians who have dedicated their entire careers to finding a cure for brain cancer.

Learn more about the Preston A. Wells, Jr. Center for Brain Tumor Therapy.


Recent News

Researcher turns a personal diagnosis into a…

Dr. Tyler Nelson’s diagnosis of periodic paralysis inspired a new focus in his work as a young neuroscientist at the MBI.

Tyler Nelson portrait

Turning questions into cures

In the lab of MBI researcher Dr. Catherine Flores, M.D.-Ph.D. student Cali Love is developing therapies for glioblastoma.

Cali Love

MBI researcher receives $100,000 Rare Disease…

Congratulations to Dr. Matthew Gentry, who received a $100,000 Oxford-Harrington Rare Disease Centre’s 2025 Rare Disease Scholar Award.

portrait of Matthew Gentry